Resource Hub Papers
Naturalistic Psilocybin Use is Associated with Persisting Improvements in Mental Health and Well-being: Results from a Prospective, Longitudinal Survey
This paper examines the effects of naturalistic psilocybin use outside of clinical research settings through a series of surveys. The study finds that psilocybin use is associated with lasting reductions in anxiety, depression, and alcohol misuse, as well as increased cognitive flexibility and well-being.
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors
This study explores why psychedelics help brain cells grow and change. It focuses on the 5-HT2A receptor, showing that specific parts of this receptor inside cells play a vital role in these positive effects.
Therapeutic use of psilocybin: Practical considerations for dosing and administration
This article aims to provide health care professionals with an overview of practical considerations for psilocybin therapy, such as pharmacology, dosing, administration, safety, and interactions. It aims to enhance healthcare professionals' knowledge and comfort in discussing and advising patients on psilocybin therapy to ensure better patient care and safety.
Classical psychedelics for the treatment of depression and anxiety: A systematic review
This review explores the potential of psychedelic-assisted therapy, using substances like ayahuasca, psilocybin, and LSD, as a promising alternative for treatment-resistant depression and anxiety. Based on the analysis of seven studies involving 130 patients, these psychedelics consistently demonstrated immediate and significant antidepressant and antianxiety effects with good safety profiles.
Psychedelics as Medicines: An Emerging New Paradigm
This paper discusses the growing scientific interest in psychedelics like psilocybin and LSD, exploring their potential for treating anxiety, depression, addiction, and inflammatory diseases through unique brain network mechanisms, suggesting a novel approach to therapy.
Structure–activity relationships of serotonin 5-HT2A agonists
This paper explores the crucial role of the 5-HT2A receptor in the brain's cognitive function, focusing on its significance as the main target for psychedelics. The study delves into the receptor's response to different chemical classes and its association with hallucinogenic effects, drawing insights from human-based research.
Psilocybin for treatment-resistant depression
This paper investigates the effects of psilocybin treatment on patients with treatment-resistant depression using functional MRI. It reveals changes in brain connectivity and blood flow that correlate with reduced depressive symptoms, suggesting a potential therapeutic mechanism.
Psychedelic Therapy + Cancer Patients
This study examines the impact of psilocybin on depression and anxiety in cancer patients. Conducted as a randomized trial, the research reveals that high doses of psilocybin significantly reduce symptoms of depression and anxiety, leading to improved quality of life, well-being, and decreased death anxiety.
This comprehensive review takes a deep dive into the world of psychedelics, covering their historical use, safety profile, mechanisms of action, effects on perception, and potential therapeutic applications. The review offers a multifaceted exploration of psychedelics' intriguing history and promising future in the field of mental health.